Perspectiva biosemiótica del eje microbiota-intestino-cerebro

Autores/as

  • Rebeca Méndez-Veras Instituto de Investigaciones Químicas, Biológicas, Biomédicas y Biofísicas, Universidad Mariano Gálvez de Guatemala

DOI:

https://doi.org/10.48160/18532330me14.362

Palabras clave:

microbiota, biosemiótica, microbioma, eje-microbiota-intestino-cerebro, Umwelt

Resumen

La influencia de la microbiota en el comportamiento, la percepción y diversas facultades cognitivas se ha estudiado en diferentes especies, incluidos el humano. Mas directamente se observa por alteraciones en la microbiota intestinal de pacientes con enfermedades neuropsiquiátricas. Los aportes que el estudio de signos y significado enriquecen la información producida por la metagenómica. Este trabajo presenta una introducción al tema de la microbiota/microbioma desde la biosemiótica, usando la teoría del Umwelt y el circulo funcional Uexkülliano como plataforma, no porque sean las únicas, sino por ser parte de los pilares de esta disciplina.

Citas

Amon, P. e I. Sanderson (2017), “What is the Microbiome?”, Archives of Disease in Childhood - Education and Practice, 102(5): 257-260. https://doi.org/10.1136/ARCHDISCHILD-2016-311643

Arnoriaga-Rodríguez, M. y J. M. Fernández-Real (2019), “Microbiota Impacts on Chronic Inflammation and Metabolic Syndrome - Related Cognitive Dysfunction”, Reviews in Endocrine and Metabolic Disorders 20(4): 473–480. https://doi.org/10.1007/s11154-019-09537-5

Badal, V. D., Wright, D., Katsis, Y., Kim, H. C., Swafford, A. D., Knight, R. y C. N. Hsu (2019), “Challenges In the Construction of Knowledge Bases for Human Microbiome-Disease Associations”, Microbiome 7(1): 129. https://doi.org/10.1186/s40168-019-0742-2

Barbieri, M. (2009), “A Short History of Biosemiotics”, Biosemiotics 2(2): 221-245. https://doi.org/10.1007/s12304-009-9042-8

Bharti, R. y D. G. Grimm (2021), “Current Challenges and Best-Practice Protocols for Microbiome Analysis”, Briefings in Bioinformatics 22(1): 178-193. https://doi.org/10.1093/bib/bbz155

Boem, F., Greslehner, G. P., Konsman, J. P. y L. Chiu (2023), “Minding the Gut: Extending Embodied Cognition and Perception to the Gut Complex”, Frontiers in Neuroscience 17: 1172783. https://doi.org/10.3389/FNINS.2023.1172783/BIBTEX

Castro García, O. (2011), “La biosemiótica y la biología cognitiva en organismos sin sistema nervioso”, Ludus Vitalis: Revista de Filosofía de las ciencias de la vida 19(36): 47-84. https://dialnet.unirioja.es/servlet/articulo?codigo=5638103&info=resumen&idioma=ENG

Castro García, Ò. (2015), Filosofía de la Biología Cognitiva. Enfoque biosemiótico de la cognición en organismos sin sistema nervioso: El caso de los Mixomicetos, Tesis doctoral, Barcelona: Universitat Autònoma de Barcelona.

Cerdó, T., Diéguez, E. y C. Campoy (2020), “Impact of Gut Microbiota on Neurogenesis and Neurological Diseases During Infancy”, Current Opinion in Pharmacology 50: 33-37. https://doi.org/10.1016/J.COPH.2019.11.006

Musso, C. G. (2020), “Biosemiotic Medicine: From an Effect-based Medicine to a Process-based Medicine”, Archivos Argentinos de Pediatría 118(5): 449-453. https://doi.org/10.5546/AAP.2020.ENG.E449

Clapp, M., Aurora, N., Herrera, L., Bhatia, M., Wilen, E. y S. Wakefield (2017), “Gut Microbiota’s Effect on Mental Health: The Gut-Brain Axis”, Clinics and Practice 7(4): 987. https://doi.org/10.4081/cp.2017.987

Costea, P. I., Hildebrand, F., Manimozhiyan, A., Bäckhed, F., Blaser, M. J., Bushman, F. D., De Vos, W. M., Ehrlich, S. D., Fraser, C. M., Hattori, M., Huttenhower, C., Jeffery, I. B., Knights, D., Lewis, J. D., Ley, R. E., Ochman, H., O’Toole, P. W., Quince, C., Relman, D. A. y P. Bork (2017), “Enterotypes in the Landscape of Gut Microbial Community Composition”, Nature Microbiology 3(1): 8-16. https://doi.org/10.1038/s41564-017-0072-8

Craven, L. J., Silverman, M. y J. P. Burton (2017), “Transfer of Altered Behaviour and Irritable Bowel Syndrome with Diarrhea (IBS-D) Through Fecal Microbiota Transplant in Mouse Model Indicates Need for Stricter Donor Screening Criteria”, Annals of Translational Medicine 5(24): 490. https://doi.org/10.21037/atm.2017.10.03

Cryan, J. F., O’Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., Guzzetta, K. E., Jaggar, M., Long-Smith, C. M., Lyte, J. M., Martin, J. A., Molinero-Perez, A., Moloney, G., Morelli, E., Morillas, E., O'Connor, R., Cruz-Pereira J. S., Peterson, V. L., Rea, K., Ritz, N. L., Sherwin, E., Spichak, S., Teichman, E. M., van de Wouw, M., Ventura-Silva, A. P., Wallace-Fitzsimons, S. E., Hyland, N., Clarke, G. y T. G. Dinan (2019), “The Microbiota-Gut-Brain Axis”. Physiology Review 99: 1877-2013. https://doi.org/10.1152/physrev.00018.2018.

Desbonnet, L., Clarke, G., Traplin, A., O’Sullivan, O., Crispie, F., Moloney, R. D., Cotter, P. D., Dinan, T. G. y J. F. Cryan (2015), “Gut Microbiota Depletion from Early Adolescence in Mice: Implications for Brain and Behaviour”, Brain, Behavior, and Immunity 48: 165-173. https://doi.org/10.1016/j.bbi.2015.04.004

Dietert, R. y J. Dietert (2012), “The Completed Self: An Immunological View of the Human-Microbiome Superorganism and Risk of Chronic Diseases”, Entropy 14(11): 2036-2065. https://doi.org/10.3390/e14112036

Feiten, T. E. (2020), “Mind After Uexküll: A Foray Into the Worlds of Ecological Psychologists and Enactivists”, Frontiers in Psychology 11: 480. https://doi.org/10.3389/fpsyg.2020.00480

Fung, T. C. (2019), “The Microbiota-Immune Axis as a Central Mediator of Gut-brain Communication”, Neurobiology of Disease 136: 104714. https://doi.org/10.1016/j.nbd.2019.104714

Fung, T. C., Vuong, H. E., Luna, C. D. G., Pronovost, G. N., Aleksandrova, A. A., Riley, N. G., Vavilina, A., McGinn, J., Rendon, T., Forrest, L. R. y E. Y. Hsiao (2019), “Intestinal Serotonin and Fluoxetine Exposure Modulate Bacterial Colonization in the Gut”, Nature Microbiology 4(12): 2064-2073. https://doi.org/10.1038/S41564-019-0540-4

Ganci, M., Suleyman, E., Butt, H. y M. Ball (2019), “The Role of the Brain–Gut–Microbiota Axis in Psychology: The Importance of Considering Gut Microbiota in the Development, Perpetuation, and Treatment of Psychological Disorders”, Brain and Behavior 9(11): e01408. https://doi.org/10.1002/brb3.1408

Gilbert, S. F., Rosenberg, E. y I. Zilber-Rosenberg (2018), “The Holobiont With Its Hologenome Is A Level Of Selection In Evolution”, en Gissis, S. B., Lamm, E. y A. Shavit (eds,), Landscapes Of Collectivity In The Life Sciences, Cambridge, MA: The MIT Press, pp. 305-324. https://works.swarthmore.edu/fac-biology/549

Goli, F. (2016), “Biosemiotic Medicine: Healing in the World of Meaning”, International Journal of Body, Mind and Culture 3(2): 132-137. https://doi.org/10.22122/ijbmc.v3i2.70

Goli, F. (2024), “Biosemiotic Medicines: Symbolic Formulations for Placebo Enhancements”, Journal of Education and Health Promotion 13(1): 156. https://doi.org/10.4103/jehp.jehp_1888_23

Goli, F., Rafieian, S. y S. Atarodi (2016), “An Introduction to the Semiotic Approach to the Placebo Responses”, en Goli, F. (ed.), Biosemiotic Medicine. Studies in Neuroscience, Consciousness and Spirituality, vol. 5, Cham: Springer, pp. 1-21. https://doi.org/10.1007/978-3-319-35092-9_1

Gordo, I. (2019), “Evolutionary Change in the Human Gut Microbiome: From a Static to A Dynamic View”, PLoS Biology 17(2): e3000126. https://doi.org/10.1371/journal.pbio.3000126

Grigoryan, Z., Shen, M. J., Twardus, S. W., Beuttler, M. M., Chen, L. A. y A. Bateman-House (2020), “Fecal Microbiota Transplantation: Uses, Questions, and Ethics”, Medicine in Microecology 6: 100027. https://doi.org/10.1016/j.medmic.2020.100027

Gupta, V. K., Paul, S. y C. Dutta (2017), “Geography, Ethnicity or Subsistence-Specific Variations in Human Microbiome Composition and Diversity”, Frontiers in Microbiology 8: 1162. https://doi.org/10.3389/fmicb.2017.01162

Guzzetta, K. E., Cryan, J. F. y O. F. O’Leary (2022), “Microbiota-Gut-Brain Axis Regulation of Adult Hippocampal Neurogenesis”, Brain Plasticity 8(1): 97-119. https://doi.org/10.3233/BPL-220141

Hatton, I. A., Galbraith, E. D., Merleau, N. S. C., Miettinen, T. P., Smith, B. M. D. y J. A. Shander (2023), “The Human Cell Count and Size Distribution”, Proceedings of the National Academy of Sciences of the United States of America, 120(39): e2303077120. https://doi.org/10.1073/PNAS.2303077120

Hendlin, Y. H. (2021), “Expanding the Reach of Biosemiotics”, Biosemiotics 14(1): 1-4. https://doi.org/10.1007/s12304-021-09425-z

Heredia, J. M. (2021), “The Uexküllian Concept of Surrounding World and Its Displacements”, Universitas Philosophica 38(76): 15-47. https://doi.org/10.11144/Javeriana.uph38-76.cumc

Iannone, L. F., Preda, A., Blottière, H. M., Clarke, G., Albani, D., Belcastro, V., Carotenuto, M., Cattaneo, A., Citraro, R., Ferraris, C., Ronchi, F., Luongo, G., Santocchi, E., Guiducci, L., Baldelli, P., Iannetti, P., Pedersen, S., Petretto, A., Provasi, S. y P. Striano (2019), “Microbiota-gut Brain Axis Involvement in Neuropsychiatric Disorders”, Expert Review of Neurotherapeutics 19(10): 1037-1050. https://doi.org/10.1080/14737175.2019.1638763

Johnson, K. V. A. y K. R. Foster (2018), “Why Does the Microbiome Affect Behaviour?”, Nature Reviews Microbiology 16(10): 647-655. https://doi.org/10.1038/s41579-018-0014-3

Kim, D., Zeng, M. Y. y G. Núñez (2017), “The Interplay between Host Immune Cells and Gut Microbiota in Chronic Inflammatory Diseases”, Experimental and Molecular Medicine 49(5): e339. https://doi.org/10.1038/emm.2017.24

Kodikara, S., Ellul, S. y K. A. Le Cao (2022), “Statistical Challenges in Longitudinal Microbiome Data Analysis”, Briefings in Bioinformatics 23(4): bbac273. https://doi.org/10.1093/bib/bbac273

Kull, K. (2019), “Jakob von Uexküll and the Study of Primary Meaning-Making”, en Michelini, F. y K. Köchy (eds.), Jakob von Uexküll and Philosophy: Life, Environments, Anthropology, Abingdon, Oxon: Routledge, pp. 220-237. https://doi.org/10.4324/9780429279096-14/JAKOB-VON-UEXK

Lavazza, A. y V. A. Sironi (2019), Are We Ready for a “Microbiome-Guided Behaviour” Approach?”, Cambridge Quarterly of Healthcare Ethics 28(4): 708-724. https://doi.org/10.1017/S0963180119000653

Lombardi, M. y J. Troisi (2021), “Gut Reactions: How Far Are We from Understanding and Manipulating the Microbiota Complexity and the Interaction with Its Host? Lessons from Autism Spectrum Disorder Studies”, Nutrients 13(10): 3492. https://doi.org/10.3390/NU13103492/S1

Lu, J., Lu, L., Yu, Y., Cluette-Brown, J., Martin, C. R. y E. C. Claud (2018), “Effects of Intestinal Microbiota on Brain Development in Humanized Gnotobiotic Mice”, Scientific Reports 8(1): 5443. https://doi.org/10.1038/S41598-018-23692-W

Luczynski, P., Whelan, S. O., O’Sullivan, C., Clarke, G., Shanahan, F., Dinan, T. G. y J. F. Cryan (2016), “Adult Microbiota-Deficient Mice Have Distinct Dendritic Morphological Changes: Differential Effects in the Amygdala and Hippocampus”, European Journal of Neuroscience 44(9): 2654-2666. https://doi.org/10.1111/EJN.13291

Lyon, P. (2015), “The Cognitive Cell: Bacterial Behavior Reconsidered”, Frontiers in Microbiology 6: 364. https://doi.org/10.3389/fmicb.2015.00264

Mousa, W. K., Chehadeh, F. y S. Husband (2022), “Recent Advances in Understanding the Structure and Function of the Human Microbiome”, Frontiers in Microbiology 13: 825338. https://doi.org/10.3389/fmicb.2022.825338

Neufeld, K. M., Kang, N., Bienenstock, J. y J. A. Foster (2011), “Reduced Anxiety-Like Behavior and Central Neurochemical Change in Germ-Free Mice”, Neurogastroenterology and Motility 23(3): 255-264, e119. https://doi.org/10.1111/J.1365-2982.2010.01620.X

Ogbonnaya, E. S., Clarke, G., Shanahan, F., Dinan, T. G., Cryan, J. F. y O. F. O’Leary (2015), “Adult Hippocampal Neurogenesis Is Regulated by the Microbiome”, Biological Psychiatry 78(4): e7-e9. https://doi.org/10.1016/j.biopsych.2014.12.023

O’Mahony, S. M., Clarke, G., Borre, Y. E., Dinan, T. G. y J. F. Cryan (2015), Serotonin, Tryptophan Metabolism and the Brain-Gut-Microbiome Axis”, Behavioural Brain Research 277: 32-48. https://doi.org/10.1016/j.bbr.2014.07.027

Palacios-García, I. y F. J. Parada (2020), “Measuring the Brain-Gut Axis in Psychological Sciences: A Necessary Challenge”, Frontiers in Integrative Neuroscience 13: 73. https://doi.org/10.3389/fnint.2019.00073

Palacios-García, I. y F. J. Parada (2021), “The Holobiont Mind: A Bridge between 4E Cognition and the Microbiome”, Adaptive Behavior 31(5):487-496. https://doi.org/10.1177/10597123211053071

Parke, E. C., Calcott, B. y M. A. O’Malley (2018), “A Cautionary Note for Claims About the Microbiome’s Impact on the ‘Self’”, PLoS Biology 16(9): e2006654. https://doi.org/10.1371/journal.pbio.2006654

Pérez, A. O. (2018), “La influencia de Jakob von Uexküll en la filosofía alemana del siglo XX”, Ensayos de Filosofia 8(2): 9.

Rea, K., Dinan, T. G. y J. F. Cryan (2020), Gut Microbiota: A Perspective for Psychiatrists”, Neuropsychobiology 79(1): 50-62. https://doi.org/10.1159/000504495

Robinson, J. M. y R. Cameron (2020), “The Holobiont Blindspot: Relating Host-Microbiome Interactions to Cognitive Biases and the Concept of the ‘Umwelt’”, Frontiers in Psychology 11: 591071. https://doi.org/10.3389/fpsyg.2020.591071

Rosenberg, E. e I. Zilber-Rosenberg (2018), “The Hologenome Concept of Evolution After 10 Years”, Microbiome 6(1): 78. https://doi.org/10.1186/s40168-018-0457-9

Rosenberg, E. e I. Zilber-Rosenberg (2019), “The Hologenome Concept of Evolution: Medical Implications”, Rambam Maimonides Medical Journal 10(1): e0005. https://doi.org/10.5041/RMMJ.10359

Roth, W., Zadeh, K., Vekariya, R., Ge, Y. y M. Mohamadzadeh (2021), “Tryptophan Metabolism and Gut-Brain Homeostasis”, International Journal of Molecular Sciences 22(6): 1-23. https://doi.org/10.3390/ijms22062973

Sahu, A., Gopalakrishnan, L., Gaur, N., Chatterjee, O., Mol, P., Modi, P. K., Dagamajalu, S., Advani, J., Jain, S. y T. S. Keshava Prasad (2018), “The 5-Hydroxytryptamine Signaling Map: An Overview of Serotonin-Serotonin Receptor Mediated Signaling Network”, Journal of Cell Communication and Signaling 12(4): 731-735. https://doi.org/10.1007/S12079-018-0482-2

Sampson, T. R. y S. K. Mazmanian (2015), “Control of Brain Development, Function, and Behavior by the Microbiome”, Cell Host and Microbe 17(5): 565-576. https://doi.org/10.1016/j.chom.2015.04.011

Sarkar, A., Harty, S., Lehto, S. M., Moeller, A. H., Dinan, T. G., Dunbar, R. I. M., Cryan, J. F. y P. W. J. Burnet (2018), “The Microbiome in Psychology and Cognitive Neuroscience”, Trends in Cognitive Sciences 22(7): 611-636. https://doi.org/10.1016/j.tics.2018.04.006

Schneider, T. (2021), “The Holobiont Self: Understanding Immunity in Context”, History and Philosophy of the Life Sciences 43(3): 99. https://doi.org/10.1007/s40656-021-00454-y

Sender, R., Fuchs, S. y R. Milo (2016a), “Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans”, Cell 164(3): 337-340. https://doi.org/10.1016/j.cell.2016.01.013

Sender, R., Fuchs, S. y R. Milo (2016b), “Revised Estimates for the Number of Human and Bacteria Cells in the Body”, PLoS Biology 14(8): e1002533. https://doi.org/10.1371/journal.pbio.1002533

Severance, E. G. y R. H. Yolken (2020), “Deciphering Microbiome and Neuroactive Immune Gene Interactions in Schizophrenia”, Neurobiology of Disease 135: 104331. https://doi.org/10.1016/j.nbd.2018.11.016

Sharov, A. A. y T. Vehkavaara (2015), “Protosemiosis: Agency with Reduced Representation Capacity”, Biosemiotics 8(1): 103-123. https://doi.org/10.1007/s12304-014-9219-7

Simon, J. C., Marchesi, J. R., Mougel, C. y M. A. Selosse (2019), “Host-Microbiota Interactions: From Holobiont Theory to Analysis”, Microbiome 7(1): 5. https://doi.org/10.1186/s40168-019-0619-4

Suárez, J. (2021), “The Holobiont/Hologenome as a Level of Selection: An Approach to the Evolution of Multispecies Systems”, Theoria 36(1): 81-112. https://doi.org/10.1387/THEORIA.21611

Treisman, G. J. (2017), “The Role of the Brain-Gut-Microbiome in Mental Health and Mental Disorders”, en Floch, M. H., Ringel, Y. y W. A. Walker (eds.), The Microbiota in Gastrointestinal Pathophysiology: Implications for Human Health, Prebiotics, Probiotics and Dysbiosis, London, UK: Academic Press, pp. 389-397. https://doi.org/10.1016/B978-0-12-804024-9/00042-2

Triviño, V. y J. Suárez (2020), “Holobionts: Ecological Communities, Hybrids, or Biological Individuals? A Metaphysical Perspective on Multispecies Systems”, Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 84: 101323. https://doi.org/10.1016/j.shpsc.2020.101323

Zengiaro, N. (2023), “The Circulation of Meaning: A Biosemiotic Perspective on the Functional Circle”, Punctum International Journal of Semiotics 9(2): 209-225. https://doi.org/10.18680/hss.2023.0026

Zilber-Rosenberg, I. y E. Rosenberg (2021), “Microbial-Driven Genetic Variation in Holobionts”, FEMS Microbiology Reviews 45(6): fuab022. https://doi.org/10.1093/femsre/fuab022

Descargas

Publicado

2024-04-30

Cómo citar

Méndez-Veras, R. . (2024). Perspectiva biosemiótica del eje microbiota-intestino-cerebro. Metatheoria – Revista De Filosofía E Historia De La Ciencia, 14(2), 33–47. https://doi.org/10.48160/18532330me14.362